6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

Base Information

Chemical Name:6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene
CAS No.:1246669-50-0
Molecular Formula:C₂₅H₂₆ClN₇
Molecular Weight:459.981
Hs Code.:

Synonyms:6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

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Chemical Property of 6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

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Technology Process of 6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

There total 3 articles about 6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17532-19-3
1-(2-chloro-benzyl)-piperazine

: 1246669-49-7
6-benzyl-4-methanesulfonyl-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

: 1246669-50-0
6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 64h;

Reference yield:

: 1246672-04-7
ethyl ester of 4-(N-benzyl-N-(3-methoxy-3-oxopropyl)amino)-6-chloro-2-methyl-thio-pyrimidine-5-carboxylic acid

: 1246669-50-0
6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

1.2: 24 h / 75 - 80 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

2.2: 1 h / 20 °C

3.1: hydrazine hydrate / methanol / 1 h / 20 °C

3.2: 0.5 h / 20 °C

3.3: 24 h / 80 - 85 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 64 h / 100 °C

With potassium tert-butylate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1246672-06-9
8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

: 1246669-50-0
6-benzyl-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-2,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / methanol / 1 h / 20 °C

1.2: 0.5 h / 20 °C

1.3: 24 h / 80 - 85 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 64 h / 100 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; dimethyl sulfoxide;