8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

Base Information

Chemical Name:8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate
CAS No.:1246672-06-9
Molecular Formula:C₁₆H₁₄F₃N₃O₄S₂
Molecular Weight:433.432
Hs Code.:

Synonyms:8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

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Chemical Property of 8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

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Technology Process of 8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

There total 5 articles about 8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1246672-05-8
8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

: 1246672-06-9
8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

Guidance literature:: 8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one; With triethylamine; In dichloromethane; at 0 ℃; for 1h;

trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1979-98-2
4,6-dihydroxy-2-methylmercaptopyrimidine

: 1246672-06-9
8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 6 h / 105 - 110 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 °C

2.2: 4 h / -78 °C

3.1: triethylamine / tetrahydrofuran / 20 h / Cooling with ice

4.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

4.2: 24 h / 75 - 80 °C

5.1: triethylamine / dichloromethane / 1 h / 0 °C

5.2: 1 h / 20 °C

With potassium tert-butylate; triethylamine; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 959070-42-9
4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester

: 1246672-06-9
8-benzyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl-trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 20 h / Cooling with ice

2.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

2.2: 24 h / 75 - 80 °C

3.1: triethylamine / dichloromethane / 1 h / 0 °C

3.2: 1 h / 20 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;