[3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt

Base Information

• Chemical Name: [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt
• CAS No.: 1369390-39-5
• Molecular Formula: C₂F₃O₂*C₃₅H₄₇Cl₂N₄O₅S
• Molecular Weight: 819.77
• Mol file: 1369390-39-5.mol

Synonyms:[3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt

Chemical Property of [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt

There total 4 articles about [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid (883969-08-2) + C11H25N2(1+) (1369390-92-0) + trifluoroacetic acid (76-05-1) → [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt (1369390-39-5)

Guidance literature:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

C₁₁H₂₅N₂⁽¹⁺⁾; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

trifluoroacetic acid; In water;

DOI:10.1016/j.bmc.2012.01.036

Reference yield:

4-(3-Methanesulfonyloxy-propyl)-piperidine-1-carboxylic acid tert-butyl ester (203859-94-3) → [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt (1369390-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / ethanol; N,N-dimethyl-formamide / 48 h / 80 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

3.2: 0 - 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.01.036

Reference yield:

CH3O3S(1-)*C16H33N2O2(1+) → [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt (1369390-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

2.2: 0 - 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.01.036

upstream raw materials:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid

C₁₁H₂₅N₂⁽¹⁺⁾

trifluoroacetic acid

4-(3-Methanesulfonyloxy-propyl)-piperidine-1-carboxylic acid tert-butyl ester