2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

Base Information

Chemical Name:2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine
CAS No.:1374675-85-0
Molecular Formula:C₂₀H₁₈Cl₂F₆N₄O₃S
Molecular Weight:579.35
Hs Code.:

2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

Synonyms:2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

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Chemical Property of 2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

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Technology Process of 2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

There total 4 articles about 2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1374675-84-9
2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

: 1374675-85-0
2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 - 40 ℃; for 138h;

Reference yield:

: 1374675-83-8
2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester

: 1374675-85-0
2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 138 h / 25 - 40 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 903129-71-5
tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

: 1374675-85-0
2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 25 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 138 h / 25 - 40 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;