4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

Base Information

Chemical Name:4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile
CAS No.:439612-49-4
Molecular Formula:C₂₁H₁₆F₆N₂O
Molecular Weight:426.361
Hs Code.:

Synonyms:4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

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Chemical Property of 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

Chemical Property:

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Technology Process of 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

There total 4 articles about 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 439612-48-3
4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzyl bromide

: 439612-49-4
4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

Guidance literature:: In N-methyl-acetamide; water;

Reference yield:

: 439612-46-1
4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzaldehyde

: 439612-49-4
4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / NaBH₄ / methanol / 20 °C

2: 55 percent / PPh₃Br₂; AcCN; pyridnine

3: 74 percent / dimethylformamide / 50 °C

With pyridine; sodium tetrahydroborate; dibromotriphenylphosphorane; 1,1'-azobis(1-cyanocyclohexanenitrile); In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.02.028

Reference yield:

: 439612-47-2
4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzyl alcohol

: 439612-49-4
4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenylacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / PPh₃Br₂; AcCN; pyridnine

2: 74 percent / dimethylformamide / 50 °C

With pyridine; dibromotriphenylphosphorane; 1,1'-azobis(1-cyanocyclohexanenitrile); In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.02.028