3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one

Base Information

• Chemical Name: 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one
• CAS No.: 1187745-66-9
• Molecular Formula: C₂₅H₂₇NO₄
• Molecular Weight: 405.494

Synonyms:3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one

Chemical Property of 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one

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Technology Process of 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one

There total 1 articles about 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide (1187745-64-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one (1187745-66-9)

Guidance literature:

4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide; With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 4h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm9013373

Reference yield: 88.0%

3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one (1187745-66-9) → 5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-1H-benzo[e]isoindole-1,3(2H)-dione (1187745-68-1)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm9013373

upstream raw materials:

4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide

N,N-dimethyl-formamide

Downstream raw materials:

5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-1H-benzo[e]isoindole-1,3(2H)-dione

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