1187745-64-7

Basic information

• Product Name: 4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide
• Synonyms: 4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide
• CAS NO: 1187745-64-7
• Molecular Weight: 377.483
• Mol File: 1187745-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide(1187745-64-7)
• EPA Substance Registry System: 4-ethyl-6,7-dimethoxy-N-(2-phenylpropan-2-yl)-1-naphthamide(1187745-64-7)

Safety Data

• Hazardous Substances Data: 1187745-64-7(Hazardous Substances Data)

Upstream product

• 585-32-0 2-phenyl-2-propylamine 

Downstream Products

• 1187745-66-9 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one 

Relevant articles and documents

Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode

Benzo[e]isoindole-1,3-dione derivatives were synthesized, and the effects on GSK-3β activity and zebrafish embryo growth were evaluated.Aseries of derivatives show obvious inhibitory activity against GSK-3β. The most potent inhibitor, 7,8-dimethoxy-5-methylbenzo[e]isoindole-1,3-dione (8a), shows nanomolar IC50 and obvious phenotype on zebrafish embryo growth associated with the inhibition of GSK-3β at low micromolar concentration. The interaction mode between 8a and GSK-3β was characterized by computational modeling. 2009 American Chemical Society.