5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

Base Information

Chemical Name:5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid
CAS No.:942589-68-6
Molecular Formula:C₁₆H₂₂INO₃S
Molecular Weight:435.326
Hs Code.:

Synonyms:5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

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Chemical Property of 5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

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Technology Process of 5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

There total 1 articles about 5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942589-47-1
methyl 5-iodo-3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate

: 942589-68-6
5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

Guidance literature:: methyl 5-iodo-3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate; With methanol; sodium hydroxide; In tetrahydrofuran; for 2h;

With hydrogenchloride; In water;

Reference yield:

: 942589-78-8
2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl][1,3]oxazolo[5,4-b]pyridine

: 942589-68-6
5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

: 3-[[(4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-(4-[1,3]oxazolo[5,4-b]pyridin-2-ylphenyl)-2-thiophenecarboxylic acid

Guidance literature:: 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl][1,3]oxazolo[5,4-b]pyridine; 5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 942589-69-7
2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl][1,3]oxazolo[4,5-b]pyridine

: 942589-68-6
5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid

: 3-[[(4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-(4-[1,3]oxazolo[4,5-b]pyridin-2-ylphenyl)-2-thiophenecarboxylic acid

Guidance literature:: 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl][1,3]oxazolo[4,5-b]pyridine; 5-iodo-3-[[(trans-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h;

With hydrogenchloride; In water; pH=1;