5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile

Base Information

• Chemical Name: 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile
• CAS No.: 62-71-5
• Molecular Formula: C₂₆H₃₆N₂O₄
• Molecular Weight: 440.583
• Mol file: 62-71-5.mol

Synonyms:5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile

Chemical Property of 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile

There total 9 articles about 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

N-methylveratrylamine (63-64-9) + 2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile (27487-83-8) → 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile (62-71-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

(3,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester (1449378-26-0) → 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile (62-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2: trifluoroacetic acid / dichloromethane / 8 h

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With sodium hydride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline (102421-43-2) → 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile (62-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 6 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 8 h

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With sodium hydride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.05.022

upstream raw materials:

N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline

(3,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

N-methylveratrylamine

2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile