27487-83-8

Basic information

• Product Name: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
• Synonyms: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;5-CHLORO-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROYLVALERONITRILE;5-Chloro-2-(3,4-dimethoxyphenyl)-2-isoproplvaleronitrile;α-(3-Chloropropyl)-(3,4-dimethoxyphenyl)isovaleronitrile;1-Chloro-5-methyl-4-cyano-4-(3,4-dimethoxyphenyl)hexane;α-(3-Chloropropyl)-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;a-(3-Chloropropyl)-3,4-dimethoxy-a-(1-methylethyl)benzeneacetonitrile
• CAS NO: 27487-83-8
• Molecular Formula: C₁₆H₂₂ClNO₂
• Molecular Weight: 295.80438
• EINECS: 248-490-7
• Product Categories: Aromatics Compounds;Aromatics;Intermediates;Aromatics, Intermediates
• Mol File: 27487-83-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 417.9°C at 760 mmHg
• Flash Point: 206.5°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 3.41E-07mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Refrigerator
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile(27487-83-8)
• EPA Substance Registry System: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile(27487-83-8)

Safety Data

• Hazardous Substances Data: 27487-83-8(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Intermediate for synthesis of verapamil and analogs.

InChI:InChI=1/C16H22ClNO2/c1-12(2)16(11-18,8-5-9-17)13-6-7-14(19-3)15(10-13)20-4/h6-7,10,12H,5,8-9H2,1-4H3

Upstream product

• 6940-76-7 1-iodo-3-chloro-propane 
• 20850-49-1 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 129975-51-5 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile 
• 1616284-73-1 2-(3,4-dimethoxy-phenyl)-5-{[2-(3,4-dimethoxy-phenyl)-ethyl]-ethyl-amino}-2-isopropyl-pentanenitrile 
• 1616284-75-3 2-(3,4-dimethoxy-phenyl)-5-{[2-(3,4-dimethoxy-phenyl)-ethyl]-propyl-amino}-2-isopropyl-pentanenitrile 
• 67018-85-3 norverapamil 
• 36764-88-2 5-{benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 1616284-81-1 2-(3,4-dimethoxyphenyl)-5-(4-hydroxypiperidin-1-yl)-2-isopropylpentanenitrile 
• 1616284-82-2 5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile 
• 1616284-83-3 2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile 
• 1616284-85-5 2-(3,4-dimethoxyphenyl)-2-(propan-2-yl)-5-[4-(pyridin-2-yl)piperazin-1-yl]pentanenitrile 
• 1616284-86-6 2-(3,4-dimethoxyphenyl)-5-(4-(2-fluorophenyl)piperazin-1-yl)-2-isopropylpentanenitrile 
• 62-71-5 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile 
• 1451067-59-6 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile 
• 27487-66-7 D 620 
• 105740-28-1 3-cyano-3-(3,4-dimethoxyphenyl)-6-iodo-2-methylhexane 

Relevant articles and documents

Design, synthesis and evaluation of 9-hydroxy-7H-furo [3,2-g]chromen-7-one derivatives as new potential vasodilatory agents

Two new 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives were designed, synthesized and evaluated for their in vitro vasodilatory activity. The structures of two compounds were elucidated by infrared, 1H NMR, and mass spectral data. The invitro pharmacological evaluation indicated that both of them possessed well vasodilatory activity compared with imperatorin. The molecule docking also showed two target compounds docked well with L-calcium channel (PDB code: 3G43). The result suggested that they would be potential vasodilatory agents for hypertension.

PHENYLACETONITRILE DERIVATIVES AND HAIR TONICS AND EXTERNAL PREPARATIONS FOR SKIN CONTAINING THE DERIVATIVES

A hair growth promoting composition comprising, as an effective ingredient, a phenylacetonitrile derivative or a pharmacologically acceptable salt thereof expressed by the following Formula (I): wherein each of R1 and R2 is hydrogen atom, a C1-10 alkyl group, a C2-10 alkenyl group or C2-10 acyl group, or NR1R2 may be a heterocycle having 3-7 members; R3 is a C1-5 alkyl group; and each of R4, R5 and R6 is hydrogen atom or a C1-4 alkoxy group. The present invention provides a hair growth promoting composition having excellent effects on promoting hair regrowth, preventing or inhibiting hair loss, and the like in human by compounding above-specified phenylacetonitrile derivative as a effective ingredient thereto.

Ethylamine derivatives and antihypertensives containing the same

An ethylamine derivative of formula (I): STR1 wherein A represents a carbon atom or a nitrogen atom; B represents a substituted or unsubstituted aralkyl or aryl group; C represents hydrogen, alkyl, aralkyl, or aryl, each of which may optionally be substituted or C may optionally be bonded to A to form an alkylene bridge which is optionally substituted, Q represents a substituted or unsubstituted aryl group, said group optionally being substituted by hetero atom(s) or substituent(s) optionally containing hetero atom(s); and X represents an alkylene bridge having from 2 to 20 carbon atoms and is optionally substituted with groups which include hetero atoms with the non-hetero atom substituents optionally containing hetero atoms.