27487-83-8

Basic information

• Product Name: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
• Synonyms: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;5-CHLORO-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROYLVALERONITRILE;5-Chloro-2-(3,4-dimethoxyphenyl)-2-isoproplvaleronitrile;α-(3-Chloropropyl)-(3,4-dimethoxyphenyl)isovaleronitrile;1-Chloro-5-methyl-4-cyano-4-(3,4-dimethoxyphenyl)hexane;α-(3-Chloropropyl)-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;a-(3-Chloropropyl)-3,4-dimethoxy-a-(1-methylethyl)benzeneacetonitrile
• CAS NO: 27487-83-8
• Molecular Formula: C₁₆H₂₂ClNO₂
• Molecular Weight: 295.80438
• EINECS: 248-490-7
• Product Categories: Aromatics Compounds;Aromatics;Intermediates;Aromatics, Intermediates
• Mol File: 27487-83-8.mol

Chemical Properties

• Boiling Point: 417.9°C at 760 mmHg
• Flash Point: 206.5°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 3.41E-07mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Refrigerator
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile(27487-83-8)
• EPA Substance Registry System: 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile(27487-83-8)

Safety Data

• Hazardous Substances Data: 27487-83-8(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Intermediate for synthesis of verapamil and analogs.

InChI:InChI=1/C16H22ClNO2/c1-12(2)16(11-18,8-5-9-17)13-6-7-14(19-3)15(10-13)20-4/h6-7,10,12H,5,8-9H2,1-4H3

Upstream product

• 6940-76-7 1-iodo-3-chloro-propane 
• 20850-49-1 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 129975-47-9 5-[4-(2-Chloro-phenyl)-piperazin-1-yl]-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 1616284-86-6 2-(3,4-dimethoxyphenyl)-5-(4-(2-fluorophenyl)piperazin-1-yl)-2-isopropylpentanenitrile 
• 1616284-85-5 2-(3,4-dimethoxyphenyl)-2-(propan-2-yl)-5-[4-(pyridin-2-yl)piperazin-1-yl]pentanenitrile 
• 1616284-83-3 2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile 
• 1616284-82-2 5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile 
• 1616284-81-1 2-(3,4-dimethoxyphenyl)-5-(4-hydroxypiperidin-1-yl)-2-isopropylpentanenitrile 
• 36764-88-2 5-{benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 67018-85-3 norverapamil 
• 1616284-75-3 2-(3,4-dimethoxy-phenyl)-5-{[2-(3,4-dimethoxy-phenyl)-ethyl]-propyl-amino}-2-isopropyl-pentanenitrile 
• 1616284-73-1 2-(3,4-dimethoxy-phenyl)-5-{[2-(3,4-dimethoxy-phenyl)-ethyl]-ethyl-amino}-2-isopropyl-pentanenitrile 
• 62-71-5 5-[(3,4-dimethoxy-benzyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropylpentanenitrile 
• 1451067-59-6 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile 
• 27487-66-7 D 620 
• 105740-28-1 3-cyano-3-(3,4-dimethoxyphenyl)-6-iodo-2-methylhexane 

Relevant articles and documents

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PHENYLACETONITRILE DERIVATIVES AND HAIR TONICS AND EXTERNAL PREPARATIONS FOR SKIN CONTAINING THE DERIVATIVES

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Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues

The subject invention concerns a process for preparing a single enantiomer, either R or S, of R'--NH--(CH2)3 --C(Ar)(CN)--R. The process is particularly useful for preparing verapamil, and analogues thereof, in single enantiomeric form.

Ethylamine derivatives and antihypertensives containing the same

An ethylamine derivative of formula (I): STR1 wherein A represents a carbon atom or a nitrogen atom; B represents a substituted or unsubstituted aralkyl or aryl group; C represents hydrogen, alkyl, aralkyl, or aryl, each of which may optionally be substituted or C may optionally be bonded to A to form an alkylene bridge which is optionally substituted, Q represents a substituted or unsubstituted aryl group, said group optionally being substituted by hetero atom(s) or substituent(s) optionally containing hetero atom(s); and X represents an alkylene bridge having from 2 to 20 carbon atoms and is optionally substituted with groups which include hetero atoms with the non-hetero atom substituents optionally containing hetero atoms.

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Tetrahydroisoquinoline derivatives

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Bicyclo-substituted phenylacetonitrile derivatives

The invention relates to compounds of the formula: STR1 which are useful cardiovascular agents.