12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

Base Information

Chemical Name:12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide
CAS No.:711013-49-9
Molecular Formula:C₄₈H₇₄BrNO₅
Molecular Weight:825.023
Hs Code.:

Synonyms:12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

There total 5 articles about 12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 73367-80-3
12-bromododecanoic acid

: 711013-48-8
4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenylamine

: 711013-49-9
12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

Guidance literature:: 12-bromododecanoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenylamine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo049939j

Reference yield:

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 711013-49-9
12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / p-toluenesulfonic acid / benzene / 24 h / Heating

2.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 0 °C

2.2: 84 percent / water / tetrahydrofuran

3.1: 59 percent / triethylamine; PdCl₂(PPh₃)2; CuI / 24 h / 20 °C

4.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; 4-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

4.2: 91 percent / tetrahydrofuran / 3 h / 20 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1021/jo049939j

Reference yield:

: 350230-73-8
2,5-bis(octyloxy)-4-[(triisopropylsilyl)ethynyl]benzaldehyde

: 711013-49-9
12-bromo-dodecanoic acid {4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2,5-bis-octyloxy-phenylethynyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / p-toluenesulfonic acid / benzene / 24 h / Heating

2.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 0 °C

2.2: 84 percent / water / tetrahydrofuran

3.1: 59 percent / triethylamine; PdCl₂(PPh₃)2; CuI / 24 h / 20 °C

4.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; 4-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

4.2: 91 percent / tetrahydrofuran / 3 h / 20 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1021/jo049939j