1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate

Base Information

• Chemical Name: 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate
• CAS No.: 306950-86-7
• Molecular Formula: C₂₁H₂₉NO₄
• Molecular Weight: 359.466
• Mol file: 306950-86-7.mol

Synonyms:1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate

Chemical Property of 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate

There total 7 articles about 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-mesityl-1-methoxymethoxy-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate (306950-87-8) → 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate (306950-86-7)

Guidance literature:

With trimethylsilyl bromide; 3 A molecular sieve; In dichloromethane; at 0 ℃; for 4h;

DOI:10.3987/COM-02-9467

Reference yield:

3,3-dimethylbutanoic acid chloride (7065-46-5) → 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate (306950-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 69 percent / TMSBr; 3 Angstroem molecular sieves / CH₂Cl₂ / 4 h / 0 °C

With trimethylsilyl bromide; 3 A molecular sieve; triethylamine; In dichloromethane;

Reference yield:

ethyl 2-[N-hydroxy-N-(mesitylacetyl)]amino-2-methylpropanoate (306950-81-2) → 1-hydroxy-4-mesityl-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate (306950-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 4 h / 0 - 20 °C

1.2: 80 percent / t-BuOK / dimethylformamide / 2 h / 20 °C

2.1: 69 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

3.1: 69 percent / TMSBr; 3 Angstroem molecular sieves / CH₂Cl₂ / 4 h / 0 °C

With trimethylsilyl bromide; 3 A molecular sieve; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-mesityl-1-methoxymethoxy-2,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl 3,3-dimethylbutanoate

3,3-dimethylbutanoic acid chloride

ethyl 2-[N-hydroxy-N-(mesitylacetyl)]amino-2-methylpropanoate

4-hydroxy-3-mesityl-1-methoxymethoxy-5,5-dimethyl-1,5-dihydro-2H-pyrrol-2-one