Chemical Property of Methylmalonic acid
Chemical Property:
- Appearance/Colour:white crystals
- Vapor Pressure:2.44E-05mmHg at 25°C
- Melting Point:128-130 °C(lit.)
- Refractive Index:1.4304 (estimate)
- Boiling Point:334.4 °C at 760 mmHg
- PKA:3.07, 5.76(at 25℃)
- Flash Point:170.2 °C
- PSA：74.60000
- Density:1.402 g/cm3
- LogP:-0.20830
- Storage Temp.:?20°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Water Solubility.:soluble
- XLogP3:0.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:118.02660867
- Heavy Atom Count:8
- Complexity:103
- Purity/Quality:
-
97% *data from raw suppliers
Methylmalonic Acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi,Xn,F
- Statements:
36/37/38-36-20/21/22-11
- Safety Statements:
26-36/37-16
- MSDS Files:
-
Useful:
- Canonical SMILES:CC(C(=O)O)C(=O)O
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Uses
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status. Methylmalonic acid can be used as a substrate in:Esterification reactions by various catalysts.Synthesis of pyrimidinium betaines with formamidine.Synthesis of malonic acid half thioester (MAHT).
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Biological Functions
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
