(4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole

Base Information

• Chemical Name: (4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole
• CAS No.: 1202053-69-7
• Molecular Formula: C₂₆H₂₃FN₄O₂
• Molecular Weight: 442.493
• Mol file: 1202053-69-7.mol

Synonyms:(4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole

Chemical Property of (4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole

There total 1 articles about (4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C19H16FNO2 (1202053-63-1) + benzyl bromide (100-39-0) → (4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole (1202053-69-7)

Guidance literature:

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 100 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1002/adsc.200900163

Reference yield: 91.0%

(4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methyloxy)methyl]-2-(2-fluorophenyl)-4-phenyl-4,5-dihydrooxazole (1202053-69-7) + potassium diphenylphosphine (15475-27-1,4346-39-8) → (4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)methyl]-2-(2-(diphenylphosphino)phenyl)-4-phenyl-4,5-dihydrooxazole (1202053-71-1)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1002/adsc.200900163

upstream raw materials:

C₁₉H₁₆FNO₂

benzyl bromide

Downstream raw materials:

(4R,5S)-5-[((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)methyl]-2-(2-(diphenylphosphino)phenyl)-4-phenyl-4,5-dihydrooxazole