(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

Base Information

Chemical Name:(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride
CAS No.:1383828-47-4
Molecular Formula:C₂₁H₂₁F₂N₃OS*ClH
Molecular Weight:437.941
Hs Code.:

Synonyms:(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

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Chemical Property of (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

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Technology Process of (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

There total 4 articles about (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1080028-80-3
(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione

: 1383828-47-4
(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water;

Reference yield: 79.0%

: C₂₁H₁₉F₂N₃OS

: 1383828-47-4
(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

Guidance literature:: C₂₁H₁₉F₂N₃OS; With sodium tetrahydroborate; isopropyl alcohol; In tetrahydrofuran; at 0 - 23 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 16h;

Reference yield:

: 677773-32-9
Etamicastat hydrochloride

: 1383828-47-4
(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium sulfate; triethylamine / tetrahydrofuran / 4.5 h / 20 - 23 °C / Inert atmosphere

2.1: sodium tetrahydroborate; isopropyl alcohol / tetrahydrofuran / 16 h / 0 - 23 °C

2.2: 16 h / 20 °C

With sodium tetrahydroborate; sodium sulfate; triethylamine; isopropyl alcohol; In tetrahydrofuran;