2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

Base Information

Chemical Name:2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one
CAS No.:1400093-67-5
Molecular Formula:C₂₁H₁₉N₃O₂
Molecular Weight:345.401
Hs Code.:

Synonyms:2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

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Chemical Property of 2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

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Technology Process of 2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

There total 10 articles about 2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 679809-11-1
4-(pyrrolidin-1-yl)benzoyl chloride

: 30192-48-4
N-(4-acetyl-3-hydroxy-2-nitrophenyl) acetamide

: 1400093-66-4
8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

: 1400093-67-5
2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

Guidance literature:: 4-(pyrrolidin-1-yl)benzoyl chloride; N-(4-acetyl-3-hydroxy-2-nitrophenyl) acetamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

With pyridine; sulfuric acid; acetic acid; potassium hydroxide; In dichloromethane; Further stages; Reflux;

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1400093-67-5
2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / -10 - 20 °C

2: N-tert-butylaminoborane; potassium carbonate / 1,4-dioxane; water / 48 h / Reflux

3: water; sodium hydroxide / methanol / Reflux

4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6: pyridine; potassium hydroxide / 1 h / 60 °C

7: sulfuric acid; acetic acid / 0.5 h / 110 °C

8: iron; ammonium chloride

9: 2 h / Reflux

With pyridine; thionyl chloride; oxalyl dichloride; sulfuric acid; N-tert-butylaminoborane; water; iron; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301099x

Reference yield:

: 129414-26-2
4-pyrrolidin-1-yl-benzoic acid methyl ester

: 1400093-67-5
2-methyl-8-(4-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: water; sodium hydroxide / methanol / Reflux

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: pyridine; potassium hydroxide / 1 h / 60 °C

5: sulfuric acid; acetic acid / 0.5 h / 110 °C

6: iron; ammonium chloride

7: 2 h / Reflux

With pyridine; oxalyl dichloride; sulfuric acid; water; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301099x