(R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate
CAS No.:1451091-05-6
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:(R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate

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Chemical Property of (R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate

There total 2 articles about (R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 923568-87-0
tert-butyl 5-methyl-2-oxo-3-phenylindoline-1-carboxylate

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1451091-05-6
(R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate

Guidance literature:: tert-butyl 5-methyl-2-oxo-3-phenylindoline-1-carboxylate; With C₂₆H₂₄F₆NOP; In chloroform; at -55 ℃;

methyl vinyl ketone; In chloroform; at -55 ℃; for 24h; enantioselective reaction;
DOI:10.1002/anie.201208285

Reference yield:

: 923568-87-0
tert-butyl 5-methyl-2-oxo-3-phenylindoline-1-carboxylate

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1175713-26-4
C₂₄H₂₇NO₄

: 1451091-05-6
(R)-tert-butyl 5-methyl-2-oxo-3-(3-oxobutyl)-3-phenylindoline-1-carboxylate

Guidance literature:: tert-butyl 5-methyl-2-oxo-3-phenylindoline-1-carboxylate; With C₄₆H₃₀N₂NiO₃; In dichloromethane; at 25 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

methyl vinyl ketone; In dichloromethane; at 25 ℃; for 18h; Overall yield = 89 %; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1055/s-0035-1561630