1H-Isoindole-1,3(2H)-dione, 2-((6-bromo-3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-4-oxo-2-quinazolinyl)methyl)-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-((6-bromo-3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-4-oxo-2-quinazolinyl)methyl)-
CAS No.:134700-42-8
Molecular Formula:C28H23BrN4O5
Molecular Weight:575.41
Hs Code.:
DSSTox Substance ID:DTXSID90158882
Wikidata:Q83027173
Mol file:134700-42-8.mol

Synonyms:BRN 4774587;1H-Isoindole-1,3(2H)-dione, 2-((6-bromo-3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-4-oxo-2-quinazolinyl)methyl)-;134700-42-8;C28H23BrN4O5;DTXSID90158882;C28-H23-Br-N4-O5;LS-84510

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Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-((6-bromo-3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-4-oxo-2-quinazolinyl)methyl)-

Chemical Property:

Vapor Pressure:3.04E-24mmHg at 25°C
Boiling Point:765.1°C at 760 mmHg
Flash Point:416.5°C
Density:1.61g/cm³
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:574.08518
Heavy Atom Count:38
Complexity:947

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CC2=C(C=CC(=C2)N3C(=NC4=C(C3=O)C=C(C=C4)Br)CN5C(=O)C6=CC=CC=C6C5=O)O

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-((6-bromo-3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-4-oxo-2-quinazolinyl)methyl)-

There total 4 articles about 1H-Isoindole-1,3(2H)-dione, 2-((6-bromo-3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-4-oxo-2-quinazolinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 134700-42-8
2-[6-Bromo-3-(4-hydroxy-3-morpholin-4-ylmethyl-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

3: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;

Reference yield:

: 134700-30-4
2-(6-Bromo-4-oxo-4H-benzo[d][1,3]oxazin-2-ylmethyl)-isoindole-1,3-dione

: 134700-42-8
2-[6-Bromo-3-(4-hydroxy-3-morpholin-4-ylmethyl-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / pyridine / Heating

2: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;

Reference yield:

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 134700-42-8
2-[6-Bromo-3-(4-hydroxy-3-morpholin-4-ylmethyl-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

3: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;