(6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate

Base Information

• Chemical Name: (6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate
• CAS No.: 1340543-35-2
• Molecular Formula: C₂₇H₂₈N₆O₇
• Molecular Weight: 548.555
• Mol file: 1340543-35-2.mol

Synonyms:(6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate

Chemical Property of (6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate

There total 2 articles about (6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-amino-6-(benzyloxy)-9H-purin-9-yl)methyl pivalate (152833-02-8) → (6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate (1340543-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane; toluene / 0 - 20 °C

2: dichloromethane; toluene / 6 h / 20 °C

With pyridine; In dichloromethane; toluene;

DOI:10.1021/jm201115f

Reference yield:

1-[4-nitrophenyl]-1-ethanol (6531-13-1) + C19H19N5O4 → (6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate (1340543-35-2)

Guidance literature:

In dichloromethane; toluene; at 20 ℃; for 6h;

DOI:10.1021/jm201115f

Reference yield: 79.0%

(6-(benzyloxy)-2-(((1-(4-nitrophenyl)ethoxy)carbonyl)-amino)-9H-purin-9-yl)methyl pivalate (1340543-35-2) → 1-(4-nitrophenyl)ethyl (6-(benzyloxy)-9H-purin-2-yl)carbamate (1340543-32-9)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 40h;

DOI:10.1021/jm201115f

upstream raw materials:

1-[4-nitrophenyl]-1-ethanol

(2-amino-6-(benzyloxy)-9H-purin-9-yl)methyl pivalate

Downstream raw materials:

1-(4-nitrophenyl)ethyl (6-(benzyloxy)-9H-purin-2-yl)carbamate

2-Amino-6-benzyloxypurine