2-Amino-4-methylthiazole

Base Information

• Chemical Name: 2-Amino-4-methylthiazole
• CAS No.: 1603-91-4
• Molecular Formula: C4H6N2S
• Molecular Weight: 114.171
• Hs Code.: 2934.10
• European Community (EC) Number: 216-505-6
• NSC Number: 40462
• UNII: R95713542R
• DSSTox Substance ID: DTXSID40166856
• Nikkaji Number: J568A
• Wikidata: Q27287992
• ChEMBL ID: CHEMBL505019
• Mol file: 1603-91-4.mol

Synonyms:2-Amino-4-methylthiazole;1603-91-4;4-methylthiazol-2-amine;2-Thiazolamine, 4-methyl-;4-Methyl-1,3-thiazol-2-amine;2-Amino-4-methylthiazol;Normotiroide;4-METHYL-2-THIAZOLAMINE;2-amino-4-methyl-1,3-thiazole;4-Methyl-2-thiazolylamine;MFCD00005329;Nomortiroide;Thiazole, 2-amino-4-methyl-;4-Methyl-2-aminothiazole;4-Methylthiazol-2-ylamine;4-methyl-thiazol-2-ylamine;MLS000069416;CHEMBL505019;UNII-R95713542R;EINECS 216-505-6;NSC-40462;aminomethiazole;SMR000059048;AI3-61054;R95713542R;2-AMINO-4-METHYL THIAZOLE;amino-4-methylthiazole;2-amino4-methylthiazole;Opera_ID_1655;2-amino4-methyl-thiazole;4-Methylthiazole-2-amine;4-methyl-thiazol-2-amine;2-Amino-4-methyl-thiazole;SCHEMBL48592;24T;(4-methyl-thiazol-2-yl)-amine;DTXSID40166856;2-Amino-4-methylthiazole, 98%;HMS2235K17;HMS3371K22;NSC40462;BDBM50271467;NSC 40462;STK301253;AKOS000119526;AB00403;CS-W009130;PS-5953;2-AMINO-4-METHYLTHIAZOLE [MI];NCGC00247014-01;BP-20145;SY005920;A1303;AM20080431;FT-0611131;FT-0653859;EN300-16075;A18260;W-107978;Q27287992;Z48847548;F2190-0489

Chemical Property of 2-Amino-4-methylthiazole

Chemical Property:

• Appearance/Colour: White to light yellow crystal powder
• Vapor Pressure: 0.059mmHg at 25°C
• Melting Point: 42-47 °C
• Refractive Index: 1.618
• Boiling Point: 232.505 °C at 760 mmHg
• PKA: 5.36±0.10(Predicted)
• Flash Point: 94.416 °C
• PSA: 67.15000
• Density: 1.259 g/cm³
• LogP: 1.61490
• Storage Temp.: Refrigerator
• Sensitive.: Hygroscopic
• Solubility.: soluble in Methanol
• Water Solubility.: soluble
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 114.02516937
• Heavy Atom Count: 7
• Complexity: 66.7

Purity/Quality:

99% ^*data from raw suppliers

4-Methylthiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36/37-22-20/21/22
• Safety Statements: 26-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CSC(=N1)N

Technology Process of 2-Amino-4-methylthiazole

There total 31 articles about 2-Amino-4-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

thiourea (17356-08-0) + acetone (67-64-1) → 4-methylthiazol-2-ylamine (1603-91-4)

Guidance literature:

With N-iodo-succinimide; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.molstruc.2017.05.004

Reference yield: 90.0%

acetaldehyde (75-07-0,9002-91-9) + thiourea (17356-08-0) → 4-methylthiazol-2-ylamine (1603-91-4)

Guidance literature:

With N-iodo-succinimide; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.molstruc.2017.05.004

Reference yield: 90.0%

propargyl bromide (106-96-7) + thiourea (17356-08-0) → 4-methylthiazol-2-ylamine (1603-91-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1055/s-0029-1217700

upstream raw materials:

4-Methylthiazole

2-amino-4-thiazoleacetic acid

2-amino-4-methyl-thiazole-5-carboxylic acid

thiocyanoacetone

Downstream raw materials:

2-(2-hydroxyethylamino)-4-methylthiazole

N-[4-methyl-5-(4-nitro-phenylsulfanyl)-thiazol-2-yl]-acetamide

N-(4-methylthiazol-2-yl)benzamide

2-amino-4-methyl-5-nitrothiazole

Refernces

• 1、 Yin, Xin-ying,Yang, Zhi-yu,Huang, Guo-li,Bian, Jian-jian,Wang, Deng-qiang,Wang, Qin,Teng, Ming-yu,Wang, Zheng-liang,Zhang, Jie. "Synthesis and properties of a series of iridium complexes with imidazolo[2,1-b]thiazole derivatives as primary ligands". . p. 5849 - 5856. Retrieved 2019.
• 2、 Safari, Javad,Abedi-Jazini, Zahra,Zarnegar, Zohre,Sadeghi, Masoud. "Nanochitosan: A biopolymer catalytic system for the synthesis of 2-aminothiazoles". . p. 108 - 112. Retrieved 2016.
• 3、 Potopnyk, Mykhaylo A.,Lytvyn, Roman,Danyliv, Yan,Ceborska, Magdalena,Bezvikonnyi, Oleksandr,Volyniuk, Dmytro,Gra?ulevi?ius, Juozas Vidas. "N,O π-Conjugated 4-Substituted 1,3-Thiazole BF2 Complexes: Synthesis and Photophysical Properties". . p. 1095 - 1105. Retrieved 2018.
• 4、 DAWBAA, Sam,EVREN, Asaf Evrim,GüL, ülküye Dudu,NUHA, Demokrat,YAVUZ, ?ule Aybüke,YURTTA?, Leyla. "Design and synthesis of new 4-methylthiazole derivatives: In vitro and in silico studies of antimicrobial activity". . . Retrieved 2021.
• 5、 Bode, Moira L.,Coyanis, Elena Mabel,Fernandes, Manuel A.,Fish, Muhammad Q.,Mohlala, Reagan L.. "Synthesis of 6-membered-ring fused thiazine-dicarboxylates and thiazole-pyrimidines via one-pot three-component reactions". . . Retrieved 2021/09/18.
• 6、 Liu, Xiao-Qing,Rong, Mei-Zhu,Si, Peng-Bin,Teng, Ming-Yu,Wang, Qin,Wang, Yu-Fei,Wang, Zheng-Liang,Zhang, Jie,Zhe, Hai-Feng,Zhou, Ai-Hui. "Synthesis and photoelectric properties of IrIIIcomplexes using fluorobenzylimidazole[2,1-b]thiazole derivatives as primary ligands". . p. 18796 - 18804. Retrieved 2021/10/26.