N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide

Base Information

• Chemical Name: N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide
• CAS No.: 1569294-07-0
• Molecular Formula: C₂₅H₃₁IN₆O₂S
• Molecular Weight: 606.531
• Mol file: 1569294-07-0.mol

Synonyms:N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide

Chemical Property of N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide

There total 3 articles about N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-nitrophenyl (2-((2-(N,N-diethylamino)ethyl)carbomoyl)quinoxalin-6-yl)carbamate hydrochloride (1569294-06-9) + 2-((2-iodobenzyl)thio)ethanamine (1569294-02-5) → N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide (1569294-07-0)

Guidance literature:

4-nitrophenyl (2-((2-(N,N-diethylamino)ethyl)carbomoyl)quinoxalin-6-yl)carbamate hydrochloride; With dmap; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

2-((2-iodobenzyl)thio)ethanamine; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ml400468x

Reference yield:

C15H21N5O (1569294-05-8) → N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide (1569294-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dmap / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 2.5 h / 20 °C / Inert atmosphere

With pyridine; dmap; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ml400468x

Reference yield:

2-Iodobenzyl bromide (40400-13-3) → N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide (1569294-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / water; ethanol / 2.5 h / 35 °C / Inert atmosphere

2.1: dmap / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 2.5 h / 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; water;

DOI:10.1021/ml400468x

upstream raw materials:

4-nitrophenyl (2-((2-(N,N-diethylamino)ethyl)carbomoyl)quinoxalin-6-yl)carbamate hydrochloride

2-((2-iodobenzyl)thio)ethanamine

C₁₅H₂₁N₅O

2-Iodobenzyl bromide

Downstream raw materials:

C₂₅H₃₁⁽¹²⁵⁾IN₆O₂S