N³-(1H-benzoimidazol-2-yl)-4-methoxy-N¹-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine

Base Information

• Chemical Name: N³-(1H-benzoimidazol-2-yl)-4-methoxy-N¹-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine
• CAS No.: 1569983-49-8
• Molecular Formula: C₂₅H₂₂N₆O₂
• Molecular Weight: 438.489

Synonyms:N³-(1H-benzoimidazol-2-yl)-4-methoxy-N¹-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine

Chemical Property of N³-(1H-benzoimidazol-2-yl)-4-methoxy-N¹-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine

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Technology Process of N³-(1H-benzoimidazol-2-yl)-4-methoxy-N¹-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine

There total 6 articles about N³-(1H-benzoimidazol-2-yl)-4-methoxy-N¹-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

2-chloro-1H-benzoimidazole (4857-06-1) + 4-methoxy-N1-(6-(2-methoxyphenyl)pyrimidin-4-yl)benzene-1,3-diamine (1569981-66-3) → N3-(1H-benzoimidazol-2-yl)-4-methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine (1569983-49-8)

Guidance literature:

With potassium dihydrogenphosphate; In butan-1-ol; for 48h; Reflux;

Reference yield:

4-Fluoro-3-nitroaniline (364-76-1) → N3-(1H-benzoimidazol-2-yl)-4-methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine (1569983-49-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium / 72 h / Reflux

1.2: 0.5 h / 0 °C

2.1: tert-butyl alcohol / 6 h / Reflux

3.1: triethylamine; palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C

4.1: potassium dihydrogenphosphate / butan-1-ol / 48 h / Reflux

With potassium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; sodium; triethylamine; In methanol; dichloromethane; tert-butyl alcohol; butan-1-ol;

Reference yield:

4-chloro-6-(2-methoxy-phenyl)-pyrimidine (75634-03-6) → N3-(1H-benzoimidazol-2-yl)-4-methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine (1569983-49-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tert-butyl alcohol / 6 h / Reflux

2: triethylamine; palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C

3: potassium dihydrogenphosphate / butan-1-ol / 48 h / Reflux

With potassium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; tert-butyl alcohol; butan-1-ol;

upstream raw materials:

2-chloro-1H-benzoimidazole

4-methoxy-N¹-(6-(2-methoxyphenyl)pyrimidin-4-yl)benzene-1,3-diamine

4-chloro-6-(2-methoxy-phenyl)-pyrimidine

4-Fluoro-3-nitroaniline

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