(2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Base Information

• Chemical Name: (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate
• CAS No.: 1041024-90-1
• Molecular Formula: C₂₉H₂₈F₃NO₅S
• Molecular Weight: 559.606
• Mol file: 1041024-90-1.mol

Synonyms:(2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Chemical Property of (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

There total 4 articles about (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-{[2-(trifluoromethyl)benzene]sulfonyl}aziridine (1039756-00-7) + tert-butyl 2,3-dihydro-1-oxo-3-phenyl-1H-indene-2-carboxylate (1041024-78-5) → (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate (1041024-90-1)

Guidance literature:

With O-1-adamantoyl-N-9-anthracenylmethyl cinchonium chloride; caesium carbonate; In chloroform; toluene; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja8036965

Reference yield: 75.0%

N-{[2-(trifluoromethyl)benzene]sulfonyl}aziridine (1039756-00-7) + (±)-tert-butyl 3-phenylindanone-2-carboxylate → (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate (1041024-90-1)

Guidance literature:

With C₄₅H₄₇N₂O₂⁽¹⁺⁾*Cl^(1-); caesium carbonate; In chloroform; water; toluene; at 0 ℃; for 48h; Reagent/catalyst; Temperature; enantioselective reaction; Catalytic behavior; Inert atmosphere; Resolution of racemate;

DOI:10.1002/chem.201203825

Reference yield:

2-trifluoromethylbenzenesulfonyl chloride (776-04-5) → (2R,3R)-tert-butyl 1-oxo-3-phenyl-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate (1041024-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere

2.1: caesium carbonate; C₄₅H₄₇N₂O₂⁽¹⁺⁾*Cl^(1-) / chloroform; water; toluene / 48 h / 0 °C / Inert atmosphere; Resolution of racemate

With C₄₅H₄₇N₂O₂⁽¹⁺⁾*Cl^(1-); caesium carbonate; triethylamine; In dichloromethane; chloroform; water; toluene;

DOI:10.1002/chem.201203825

upstream raw materials:

N-{[2-(trifluoromethyl)benzene]sulfonyl}aziridine

tert-butyl 2,3-dihydro-1-oxo-3-phenyl-1H-indene-2-carboxylate

2-trifluoromethylbenzenesulfonyl chloride

3-phenyl-1-indanone