3-Phenyl-1-indanone

Base Information

• Chemical Name: 3-Phenyl-1-indanone
• CAS No.: 16618-72-7
• Molecular Formula: C15H12O
• Molecular Weight: 208.26
• Hs Code.: 2914399090
• European Community (EC) Number: 625-438-5
• NSC Number: 82364
• DSSTox Substance ID: DTXSID701314027
• Nikkaji Number: J36.988H
• ChEMBL ID: CHEMBL1571712
• Mol file: 16618-72-7.mol

Synonyms:3-Phenyl-1-indanone;16618-72-7;3-Phenyl-2,3-dihydro-1H-inden-1-one;1-Indanone, 3-phenyl-;1H-Inden-1-one, 2,3-dihydro-3-phenyl-;3-Phenylindan-1-one;3-Phenylindanone;3-phenyl-2,3-dihydroinden-1-one;NSC 82364;BRN 1370263;4-07-00-01673 (Beilstein Handbook Reference);NSC82364;MLS000691949;SCHEMBL181713;3-Phenyl-1-indanone, 98%;WLN: L56 BVT&J DR;(+/-)-3-Phenyl-1-indanone;CHEMBL1571712;DTXSID701314027;HMS2629C20;AMY13690;3-phenyl-2,3-dihydro-inden-1-one;MFCD00037722;NSC-82364;AKOS004119419;AKOS016038080;1H-Inden-1-one,3-dihydro-3-phenyl-;NCGC00246563-01;LS-81336;SMR000333984;1H-Indene-1-one, 2,3-dihydro-3-phenyl-;CS-0315124;FT-0616326;9K-043;I10111;A810702;J-010263

Chemical Property of 3-Phenyl-1-indanone

Chemical Property:

• Vapor Pressure: 0.00016mmHg at 25°C
• Melting Point: 75-78 °C
• Refractive Index: 1.62
• Boiling Point: 331 °C at 760 mmHg
• Flash Point: 142.3 °C
• PSA: 17.07000
• Density: 1.162 g/cm³
• LogP: 3.40490
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 208.088815002
• Heavy Atom Count: 16
• Complexity: 265

Purity/Quality:

97% ^*data from raw suppliers

3-Phenyl-1-indanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(C2=CC=CC=C2C1=O)C3=CC=CC=C3

Technology Process of 3-Phenyl-1-indanone

There total 112 articles about 3-Phenyl-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(α-styryl)benzaldehyde (871563-46-1) → 3-phenyl-1-indanone (16618-72-7)

Guidance literature:

With hydrogen; [Rh(nbd)(dppe)]ClO₄; In diethyl ether; 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.08.061

Reference yield: 98.0%

3,3-Diphenylpropionic acid (606-83-7) → 3-phenyl-1-indanone (16618-72-7)

Guidance literature:

3,3-Diphenylpropionic acid; With pyridine; 1,3,5-trichloro-2,4,6-triazine; In dichloromethane; at 20 ℃; for 0.25h;

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.416667h;

DOI:10.1021/ol800752v

Reference yield: 94.0%

β-Phenylacrylic acid 4-nitroanilide (134430-90-3,74948-33-7) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3-phenyl-1-indanone (16618-72-7)

Guidance literature:

With trifluorormethanesulfonic acid; at 50 ℃;

upstream raw materials:

(E)-3-phenylacrylic acid

3,3-Diphenylpropionic acid

3,3-diphenylpropanoyl chloride

3-phenyl-1H-inden-1-one

Downstream raw materials:

(+/-)-2-[(Ξ)-furfurylidene-3-phenyl-indan-1-one

1-Methyl-3-phenyl-indan-1-ol

2-dimethylaminomethyl-3-phenyl-indan-1-one

3-phenyl-2-piperidinomethyl-indan-1-one; hydrochloride

Refernces

Some Amines Derived from 3-Phenyl-1-indanone

10.1021/ja01646a074

The study explores the isomerization of D-glucose to D-mannose using a resin catalyst in carbon dioxide-free water under nitrogen, yielding D-mannose phenylhydrazone. It also investigates the synthesis of amines derived from 3-phenyl-1-indanone through the Mannich reaction with various amines (dimethylamine, diethylamine, piperidine, and morpholine) and formaldehyde, resulting in low yields and unstable products. Further reductions and hydrogenations of these products led to the formation of indene derivatives and aminoalcohols, but no significant pharmacologic activity was observed. Additionally, the study examines the Mannich reaction of p-nitroacetophenone with different amines and formaldehyde, yielding p-(di)-alkylamino-p-nitropropiophenones, which were further reduced to aminoketones and reacted with phenylhydrazine to form pyrazolines.