(2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Base Information

Chemical Name:(2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine
CAS No.:249617-09-2
Molecular Formula:C₂₄H₃₉NO₅Si
Molecular Weight:449.663
Hs Code.:

Synonyms:(2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Suppliers and Price of (2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

There total 7 articles about (2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 108-24-7
acetic anhydride

: 249617-07-0
(2R,3S,4S)-2-Benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-3-hydroxypyrrolidine

: 249617-09-2
(2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Guidance literature:: With pyridine; dmap; at 20 ℃; for 3h;
DOI:10.1055/s-1999-3661

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 249617-09-2
(2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / imidazole / dimethylformamide / 20 h / 50 °C

2: H₂ / 10 percent Pd(OH)2/C / dioxane / 144 h / 20 °C / 3000.24 Torr

3: H₂ / 10 percent Pd(OH)2/C / dioxane; acetic acid / 24 h / 20 °C

4: 97 percent / pyridine; DMAP / 3 h / 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen; palladium dihydroxide; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; 1: Etherification / 2: Catalytic hydrogenation / 3: Hydrogenolysis / 4: Acetylation;
DOI:10.1055/s-1999-3661

Reference yield:

: 186465-38-3
(2R,3S,4S)-1,2-Dibenzyl-3-(benzyloxy)-4-hydroxypyrrolidine

: 249617-09-2
(2R,3S,4S)-3-Acetoxy-2-benzyl-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / imidazole / dimethylformamide / 20 h / 50 °C

2: H₂ / 10 percent Pd(OH)2/C / dioxane / 144 h / 20 °C / 3000.24 Torr

3: H₂ / 10 percent Pd(OH)2/C / dioxane; acetic acid / 24 h / 20 °C

4: 97 percent / pyridine; DMAP / 3 h / 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen; palladium dihydroxide; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; 1: Etherification / 2: Catalytic hydrogenation / 3: Hydrogenolysis / 4: Acetylation;
DOI:10.1055/s-1999-3661