tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate

Base Information

• Chemical Name: tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate
• CAS No.: 1426687-08-2
• Molecular Formula: C₃₈H₅₃ClN₆O₉
• Molecular Weight: 773.327
• Mol file: 1426687-08-2.mol

Synonyms:tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate

Chemical Property of tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate

There total 14 articles about tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl methanesulfonate (1186579-82-7) + 2-((4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide (1300746-10-4) → tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate (1426687-08-2)

Guidance literature:

With potassium carbonate; In acetonitrile; Inert atmosphere;

Reference yield:

2-Amino-5-methoxybenzoic acid (6705-03-9) → tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate (1426687-08-2)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 18 h / 140 °C / Inert atmosphere

2.1: toluene; tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 60 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 18 h / 80 °C / Inert atmosphere

5.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C

6.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

6.2: 1 h / 0 - 20 °C / Inert atmosphere

7.1: acetic acid / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

9.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

9.2: 18 h / 20 °C / Inert atmosphere

10.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere

11.1: potassium carbonate / acetonitrile / 18 h / 90 °C / Inert atmosphere

With tetraphosphorus decasulfide; boron tribromide; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone (91713-54-1) → tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate (1426687-08-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: dichloromethane / 2 h / 60 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 18 h / 80 °C / Inert atmosphere

3.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C

4.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C / Inert atmosphere

5.1: acetic acid / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

6.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

7.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

7.2: 18 h / 20 °C / Inert atmosphere

8.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere

9.1: potassium carbonate / acetonitrile / 18 h / 90 °C / Inert atmosphere

With tetraphosphorus decasulfide; boron tribromide; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

upstream raw materials:

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl methanesulfonate

2-((4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

2-Amino-5-methoxybenzoic acid

[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone