1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

Base Information

Chemical Name:1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone
CAS No.:1476848-27-7
Molecular Formula:C₁₇H₁₃BrO₃
Molecular Weight:345.192
Hs Code.:

Synonyms:1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

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Chemical Property of 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

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Technology Process of 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

There total 7 articles about 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: toluene-ethyl acetate

: 1476848-27-7
1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

Guidance literature:: With N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

: C₂₀H₂₂O₃Si

: 1476848-27-7
1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

Guidance literature:: With N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; at -25 - 0 ℃; for 2.16667h;
DOI:10.1021/acs.jmedchem.9b00186

Reference yield:

: C₁₇H₁₆O₄

: 1476848-27-7
1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 40 h / 55 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

2.2: 0.92 h / -78 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide; sodium hydrogencarbonate / tetrahydrofuran / 2.17 h / -25 - 0 °C

With N-Bromosuccinimide; sodium hydrogencarbonate; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.9b00186