6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 1476848-30-2
• Molecular Formula: C₂₀H₁₅N₃O₃S
• Molecular Weight: 377.423
• Mol file: 1476848-30-2.mol

Synonyms:6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole

There total 10 articles about 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-(4-(benzyloxy)benzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole (1476848-29-9) + sodium methylate (124-41-4) → 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole (1476848-30-2)

Guidance literature:

In methanol; dichloromethane; at 22 ℃; for 0.666667h;

DOI:10.1021/acs.jmedchem.9b00186

Reference yield:

6-(4-(benzyloxy)benzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole (1476848-29-9) → 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole (1476848-30-2)

Guidance literature:

With hydrogenchloride; sodium methylate; In methanol; dichloromethane;

Reference yield:

1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone (1476848-27-7) → 6-(4-(benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole (1476848-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl alcohol

2: hydrogenchloride; sodium methylate / methanol; dichloromethane

With hydrogenchloride; sodium methylate; In methanol; dichloromethane; isopropyl alcohol;

upstream raw materials:

1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

6-(4-(benzyloxy)benzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole

sodium methylate

5-(benzyloxy)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

Downstream raw materials:

2-Methoxy-6-(4-((2-phenylthiazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-ol