tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Base Information

Chemical Name:tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate
CAS No.:151379-88-3
Molecular Formula:C₂₆H₃₅NO₂
Molecular Weight:393.569
Hs Code.:

Synonyms:tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

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Chemical Property of tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

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Technology Process of tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

There total 19 articles about tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 151294-67-6
(1S,2R)-2-[Benzyl-((R)-1-phenyl-ethyl)-amino]-cyclohexanecarboxylic acid tert-butyl ester

: 151379-88-3
tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: With potassium hexamethylsilazane; tert-butyl alcohol; In tetrahydrofuran; for 144h; Ambient temperature;
DOI:10.1039/P19940001411

Reference yield: 58.0%

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 117471-88-2
tert-butyl (E)-7-iodohept-2-enoate

: 151379-88-3
tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl (E)-7-iodohept-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2011.09.038