(1S,2R)-(+)-2-AMINOCYCLOHEXANECARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: (1S,2R)-(+)-2-AMINOCYCLOHEXANECARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 158414-45-0
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Mol file: 158414-45-0.mol

Synonyms:(1S,2R)-CIS-2-AMINO-1-CYCLOHEXANE-CARBOXYLIC ACID HYDROCHLORIDE;(1S,2R)-(+)-2-AMINOCYCLOHEXANECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property of (1S,2R)-(+)-2-AMINOCYCLOHEXANECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.00103mmHg at 25°C
• Melting Point: 233-236 °C
• Refractive Index: 1.503
• Boiling Point: 280°Cat760mmHg
• Flash Point: 123.1°C
• PSA: 63.32000
• Density: 1.133g/cm³
• LogP: 2.09080
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(+/-)-cis-2-Aminocyclohexane-1-carboxylicacidhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2R)-(+)-2-AMINOCYCLOHEXANECARBOXYLIC ACID HYDROCHLORIDE

There total 11 articles about (1S,2R)-(+)-2-AMINOCYCLOHEXANECARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(±)-cis-N-tert-butyloxycarbonyl-2-aminocyclohexanecarboxylic acid (209128-50-7) → (±)-trans-2-aminocyclohexanecarboxylic acid hydrochloride (24716-92-5,57266-55-4,57266-57-6,107313-10-0,107313-16-6,158414-45-0)

Guidance literature:

Multi-step reaction with 4 steps

1: diisopropyl-carbodiimide; dmap / dichloromethane / 0 °C / Inert atmosphere; Heating

2: sodium methylate / methanol / Inert atmosphere; Reflux

3: sodium hydroxide / water; methanol / 16 h / 20 °C

4: hydrogenchloride / water; 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; dmap; sodium methylate; sodium hydroxide; diisopropyl-carbodiimide; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.tet.2015.11.023

Reference yield:

cyclohexene (110-83-8) → (±)-trans-2-aminocyclohexanecarboxylic acid hydrochloride (24716-92-5,57266-55-4,57266-57-6,107313-10-0,107313-16-6,158414-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 8 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: potassium carbonate / water; 1,4-dioxane / 16 h / 0 - 20 °C

3.1: diisopropyl-carbodiimide; dmap / dichloromethane / 0 °C / Inert atmosphere; Heating

4.1: sodium methylate / methanol / Inert atmosphere; Reflux

5.1: sodium hydroxide / water; methanol / 16 h / 20 °C

6.1: hydrogenchloride / water; 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; dmap; sodium methylate; potassium carbonate; sodium hydroxide; diisopropyl-carbodiimide; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.tet.2015.11.023

Reference yield:

(±)-cis-N-tert-butyloxycarbonyl-2-aminocyclohexanecarboxylic acid methyl ester → (±)-trans-2-aminocyclohexanecarboxylic acid hydrochloride (24716-92-5,57266-55-4,57266-57-6,107313-10-0,107313-16-6,158414-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / Inert atmosphere; Reflux

2: sodium hydroxide / water; methanol / 16 h / 20 °C

3: hydrogenchloride / water; 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; sodium methylate; sodium hydroxide; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.tet.2015.11.023

upstream raw materials:

C₁₁H₁₉NO₃Si

ethyl trans-2-amino-1-cyclohexanecarboxylate

(±)-cis-N-tert-butyloxycarbonyl-2-aminocyclohexanecarboxylic acid

(±)-cis-2-aminocyclohexane-1-carboxylic acid hydrochloride

Downstream raw materials:

(±)-trans-2-aminocyclohexanecarboxylic acid hydrochloride

C₇H₈O₃S*C₁₄H₁₉NO₂