2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

Base Information

Chemical Name:2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine
CAS No.:1380343-14-5
Molecular Formula:C₁₇H₂₁ClN₄O
Molecular Weight:332.833
Hs Code.:

Synonyms:2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

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Chemical Property of 2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

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Technology Process of 2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

There total 5 articles about 2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1380343-13-4
2-amino-4-chloro-7-(4-methoxy)benzyl-pyrrolidino[2,3-d]pyrimidine

: 123-72-8
butyraldehyde

: 1380343-14-5
2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

Guidance literature:: 2-amino-4-chloro-7-(4-methoxy)benzyl-pyrrolidino[2,3-d]pyrimidine; butyraldehyde; With acetic acid; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 85 ℃; for 16h;

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 1380343-14-5
2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 0.17 h / 0 °C

1.2: 18 h / 20 °C

1.3: pH 6

2.1: phosphorus pentachloride; N,N-diethylaniline; trichlorophosphate / 120 °C / Reflux

3.1: ozone / ethyl acetate / 1 h / -78 °C

4.1: acetic acid / tetrahydrofuran / 0.5 h / 20 °C

5.1: acetic acid / methanol / 0.5 h / 20 °C

5.2: 16 h / 85 °C

With phosphorus pentachloride; sodium ethanolate; ozone; acetic acid; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; ethyl acetate;

Reference yield:

: 97570-29-1
5-allyl-2-aminopyrimidine-4,6-diol

: 1380343-14-5
2-n-propylamino-4-chloro-7-(4-methoxy)benzyl-pyrrolidmo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentachloride; N,N-diethylaniline; trichlorophosphate / 120 °C / Reflux

2.1: ozone / ethyl acetate / 1 h / -78 °C

3.1: acetic acid / tetrahydrofuran / 0.5 h / 20 °C

4.1: acetic acid / methanol / 0.5 h / 20 °C

4.2: 16 h / 85 °C

With phosphorus pentachloride; ozone; acetic acid; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethyl acetate;