(R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide

Base Information

• Chemical Name: (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide
• CAS No.: 190522-06-6
• Molecular Formula: C₃₅H₄₅N₇O₆S
• Molecular Weight: 691.852

Synonyms:(R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide

Chemical Property of (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide

There total 8 articles about (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-phenyl-1H-tetrazolone (5097-82-5) → (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide (190522-06-6)

Guidance literature:

Multi-step reaction with 5 steps

1: KOH / dimethylformamide

2: nitrosonium hexafluoroborate / acetonitrile

3: H₂ / 10 percent Pd/C / ethanol

4: 1.) NaNO₂, conc. HCl, AcOH, 2.) SO₂, CuCl, AcOH / 2.) from -20 deg C to RT

5: pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; potassium hydroxide; nitrosonium hexafluoroborate; sulfur dioxide; hydrogen; acetic acid; copper(l) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00182-1

Reference yield:

phenyl isocyanate (103-71-9) → (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide (190522-06-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 92 percent / NaN₃, AlCl₃ / tetrahydrofuran

2: KOH / dimethylformamide

3: nitrosonium hexafluoroborate / acetonitrile

4: H₂ / 10 percent Pd/C / ethanol

5: 1.) NaNO₂, conc. HCl, AcOH, 2.) SO₂, CuCl, AcOH / 2.) from -20 deg C to RT

6: pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; potassium hydroxide; aluminium trichloride; sodium azide; nitrosonium hexafluoroborate; sulfur dioxide; hydrogen; acetic acid; copper(l) chloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00182-1

Reference yield:

3-cyclopentyl-1-iodopropane (106211-63-6) → (R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)Ethyl]Amino]Ethyl]Phenyl]-4-[4-(3-Cyclopentylpropyl)-5-Tetrazolon-1-Yl]Benzenesulfonamide (190522-06-6)

Guidance literature:

Multi-step reaction with 5 steps

1: KOH / dimethylformamide

2: nitrosonium hexafluoroborate / acetonitrile

3: H₂ / 10 percent Pd/C / ethanol

4: 1.) NaNO₂, conc. HCl, AcOH, 2.) SO₂, CuCl, AcOH / 2.) from -20 deg C to RT

5: pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; potassium hydroxide; nitrosonium hexafluoroborate; sulfur dioxide; hydrogen; acetic acid; copper(l) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00182-1

upstream raw materials:

(R)-N-[2-(4-aminophenyl)ethyl]-2-hydroxy-2-(3-pyridyl)ethylcarbamic acid 1,1-dimethylethyl ester

4-[(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]phenylsulfonyl chloride

5-phenyl-1H-tetrazolone

phenyl isocyanate

Downstream raw materials:

L 770644

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