ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate

Base Information

• Chemical Name: ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate
• CAS No.: 1384097-69-1
• Molecular Formula: C₂₂H₂₄N₄O₅S
• Molecular Weight: 456.522

Synonyms:ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate

Chemical Property of ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate

There total 4 articles about ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(E)-4-(benzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (1384097-59-9) + ethyl bromoacetate (105-36-2) → ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate (1384097-69-1)

Guidance literature:

(E)-4-(benzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione; With potassium carbonate; In acetone; for 0.5h; Reflux;

ethyl bromoacetate; In acetone; Reflux;

DOI:10.1016/j.bmcl.2012.03.023

Reference yield:

4-amino-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (31821-78-0) → ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate (1384097-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 2 h / Reflux

2.1: potassium carbonate / acetone / 0.5 h / Reflux

2.2: Reflux

With potassium carbonate; acetic acid; In acetone;

DOI:10.1016/j.bmcl.2012.03.023

Reference yield:

ethyl 3,4,5-trimethoxybenzoate (6178-44-5) → ethyl 2-(6-phenyl-3-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl) acetate (1384097-69-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 6 h / Reflux

2.1: potassium hydroxide / ethanol / 16 h / 20 °C

2.2: 3 h / Reflux

3.1: acetic acid / 2 h / Reflux

4.1: potassium carbonate / acetone / 0.5 h / Reflux

4.2: Reflux

With potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; acetone;

DOI:10.1016/j.bmcl.2012.03.023

upstream raw materials:

4-amino-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione

(E)-4-(benzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione

ethyl bromoacetate

ethyl 3,4,5-trimethoxybenzoate

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