Zidapamide

Base Information

Chemical Name:Zidapamide
CAS No.:75820-08-5
Molecular Formula:C16H16 Cl N3 O3 S
Molecular Weight:365.84
Hs Code.:2935009090
European Community (EC) Number:278-321-2
UNII:F7KU1MIY58
DSSTox Substance ID:DTXSID6048834
Nikkaji Number:J32.514G
Wikidata:Q27277773
NCI Thesaurus Code:C82267
ChEMBL ID:CHEMBL6378
Mol file:75820-08-5.mol

Synonyms:Zidapamide;75820-08-5;Zidapumide;Isodapamida;Isodapamidum;Zidapamida;Zidapamidum;Zipadamide;Zidapamide [INN];ISODAPAMIDE;Zidapamidum [Latin];Zidapamida [Spanish];Zidapamide [USAN:INN];Zidapamidum [INN-Latin];Isodapamidum [INN-Latin];Zidapamida [INN-Spanish];UNII-F7KU1MIY58;Isodapamida [INN-Spanish];4-chloro-N-(1-methyl-1,3-dihydroisoindol-2-yl)-3-sulfamoylbenzamide;F7KU1MIY58;DTXSID6048834;EINECS 278-321-2;Zidapamide (USAN);ZIDAPAMIDE [USAN];4-Chloro-N-(1-methyl-2-isoindolinyl)-3-sulfamoylbenzamide;CHEMBL6378;SCHEMBL2109204;DTXCID001333999;Tox21_113316;CAS-75820-08-5;FT-0710798;D08924;Q27277773;4-chloro-N-(1-methylisoindolin-2-yl)-3-sulfamoylbenzamide

Suppliers and Price of Zidapamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ZIDAPAMIDE 95.00%
5MG
$ 503.44

Total 8 raw suppliers

Chemical Property of Zidapamide

Chemical Property:

PSA：100.88000
Density:1.51g/cm³
LogP:4.31890
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:365.0600902
Heavy Atom Count:24
Complexity:580

Purity/Quality:

99% ^*data from raw suppliers

ZIDAPAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2=CC=CC=C2CN1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
Uses Zidapamide is a thiazide-like diuretic drug used in treatment of hypertension.
Therapeutic Function Antihypertensive

Technology Process of Zidapamide

There total 3 articles about Zidapamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 70049-77-3
3-(aminosulfonyl)-4-chlorobenzoyl chloride

: 75820-07-4
1-methyl-2-aminoisoindoline hydrochloride

: 75820-08-5
1-methyl-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

Guidance literature:: With triethylamine; In tetrahydrofuran; for 20h; Ambient temperature;
DOI:10.1021/jm00140a018

Reference yield:

: 35106-84-4
1-bromomethyl-2-(α-bromoethyl)benzene

: 75820-08-5
1-methyl-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / triethylamine / dimethylformamide / 3 h / Ambient temperature

2: 86 percent / concd HCl / 1.5 h / Ambient temperature

3: 67 percent / triethylamine / tetrahydrofuran / 20 h / Ambient temperature

With hydrogenchloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00140a018

Reference yield:

: 75820-06-3
1-methyl-2-<(tert-butyloxycarbonyl)amino>isoindoline

: 75820-08-5
1-methyl-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / concd HCl / 1.5 h / Ambient temperature

2: 67 percent / triethylamine / tetrahydrofuran / 20 h / Ambient temperature

With hydrogenchloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00140a018