19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

Base Information

Chemical Name:19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate
CAS No.:233768-86-0
Molecular Formula:C₃₉H₅₀O₆Si
Molecular Weight:642.908
Hs Code.:

Synonyms:19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

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Technology Process of 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

There total 1 articles about 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 233768-85-9
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

: 233768-86-0
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

Guidance literature:: With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; In dichloromethane; at -23 ℃; for 2.5h;
DOI:10.1021/jm990064o

Reference yield: 82.0%

: 233768-86-0
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

: 233768-87-1
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7β-hydroxyandrost-5-en-17β-yl acetate

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In tetrahydrofuran; methanol; for 0.5h; Ambient temperature;
DOI:10.1021/jm990064o

Reference yield:

: 233768-86-0
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-7-oxoandrost-5-en-17β-yl acetate

: 233769-07-8
3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / aq. CeCl₃, NaBH₄ / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

2: 81 percent / nBu₄NF / tetrahydrofuran / 24 h / Ambient temperature

3: 87 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: methanolic KOH / tetrahydrofuran / 1 h / 4 °C

5: 82 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr

6: 1.) aq. CeCl₃, NaBH₄, 2.) diisopropylethylamine / 1.) MeOH, THF, RT, 0.5 h, 2.) CH₂Cl₂, RT, 2 h

7: 75 percent / methanolic KOH / 3 h / 50 °C

8: 88 percent / CrO₃, pyridine / CH₂Cl₂ / 0.75 h / Ambient temperature

9: 62 percent / tetrahydrofuran; diethyl ether / 48 h / Ambient temperature

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; tetrabutyl ammonium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm990064o