19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

Base Information

Chemical Name:19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate
CAS No.:233768-85-9
Molecular Formula:C₃₉H₅₂O₅Si
Molecular Weight:628.924
Hs Code.:

Synonyms:19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

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Chemical Property of 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

Chemical Property:

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Technology Process of 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

There total 5 articles about 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 233768-84-8
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol

: 233768-85-9
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

Guidance literature:: With pyridine; for 24h; Ambient temperature;
DOI:10.1021/jm990064o

Reference yield:

: 510-64-5
19-hydroxy-4-androstene-3,17-dione

: 233768-85-9
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

2: 45 percent / p-toluenesulfonic acid / 7.5 h / 83 °C

3: 84 percent / NaBH₄ / tetrahydrofuran; H₂O / 6 h / Ambient temperature

4: 92 percent / pyridine / 24 h / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm990064o

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 233768-85-9
19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

2: 45 percent / p-toluenesulfonic acid / 7.5 h / 83 °C

3: 84 percent / NaBH₄ / tetrahydrofuran; H₂O / 6 h / Ambient temperature

4: 92 percent / pyridine / 24 h / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm990064o