L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester

Base Information

Chemical Name:L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester
CAS No.:74086-60-5
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:
DSSTox Substance ID:DTXSID201146504

Synonyms:DTXSID201146504;L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester;74086-60-5

Suppliers and Price of L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:376.19982200
Heavy Atom Count:27
Complexity:537

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)OC

Technology Process of L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester

There total 14 articles about L-Phenylalanine, 1-[(1,1-dimethylethoxy)carbonyl]-D-prolyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

: 57177-79-4,74086-60-5,52071-64-4
(S)-tert-butyl 2-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; for 1h; Milling;
DOI:10.3762/bjoc.13.217

Reference yield: 94.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 57177-79-4,74086-60-5,52071-64-4
(S)-tert-butyl 2-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-L-proline; With 4-methyl-morpholine; 4-(4,6-di[2,2,2-trifluoroethoxy]-1,3,5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo2002038