[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

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Chemical Name:[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester
CAS No.:127896-79-1
Molecular Formula:C₃₁H₃₇NO₅Si
Molecular Weight:531.724
Hs Code.:

Synonyms:[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

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Chemical Property of [(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

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Technology Process of [(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

There total 7 articles about [(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 127896-80-4
2(S)-<1'(S)-((Benzyloxycarbonyl)amino)-2'-((tert-butyldiphenylsilyl)oxy)ethyl>-2,3-dihydro-4H-pyran-4-one

: 127896-79-1
[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((2S,4S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; ethanol; at -78 ℃; for 1h;
DOI:10.1021/jo00026a031

Reference yield: 92.0%

: 127896-80-4
2(S)-<1'(S)-((Benzyloxycarbonyl)amino)-2'-((tert-butyldiphenylsilyl)oxy)ethyl>-2,3-dihydro-4H-pyran-4-one

: 127896-79-1
[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; at -78 ℃; for 3h;
DOI:10.1016/S0040-4039(01)93434-3

Reference yield:

: 1676-81-9
N-benzyloxycarbonyl-L-serine methyl ester

: 127896-79-1
[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((2S,4S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / imidazole / dimethylformamide

2: 70 percent / DIBAL / diethyl ether; toluene / 1 h / temperature below -70 deg C

3: 1. ZnBr₂, 2. trifluoroacetic acid (TFA) / 1. THF, r.t., overnight; 2. CH₂Cl₂, 5 min

4: 100 percent / CeCl₃*7H₂O, NaBH₄ / ethanol; methanol / 1 h / -78 °C

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; diisobutylaluminium hydride; trifluoroacetic acid; zinc dibromide; In methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00026a031