7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Base Information

Chemical Name:7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal
CAS No.:138286-61-0
Molecular Formula:C₃₁H₃₇NO₅Si
Molecular Weight:531.724
Hs Code.:

Synonyms:7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Suppliers and Price of 7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

There total 7 articles about 7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 127896-81-5
2(S)-<1'(S)-(Benzyloxycarbonyl)amino)-2'-((tert-butyldiphenylsilyl)oxy)ethyl>-4(R)-acetoxy-2,3-dihydro-4H-pyran

: 138286-61-0
7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Guidance literature:: With sulfuric acid; mercury(II) sulfate; In 1,4-dioxane; for 48h;
DOI:10.1021/jo00026a031

Reference yield:

: 1676-81-9
N-benzyloxycarbonyl-L-serine methyl ester

: 138286-61-0
7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / imidazole / dimethylformamide

2: 70 percent / DIBAL / diethyl ether; toluene / 1 h / temperature below -70 deg C

3: 1. ZnBr₂, 2. trifluoroacetic acid (TFA) / 1. THF, r.t., overnight; 2. CH₂Cl₂, 5 min

4: 100 percent / CeCl₃*7H₂O, NaBH₄ / ethanol; methanol / 1 h / -78 °C

5: Et₃N, DMAP / CH₂Cl₂ / 0.08 h

6: 90 percent / aq. H₂SO₄, HgSO₄ / dioxane / 48 h

With 1H-imidazole; dmap; sodium tetrahydroborate; cerium(III) chloride; sulfuric acid; diisobutylaluminium hydride; mercury(II) sulfate; triethylamine; trifluoroacetic acid; zinc dibromide; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00026a031

Reference yield:

: 135245-97-5
methyl (2S)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-2-[(phenylmethoxy)carbonylamino]propanoate

: 138286-61-0
7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / DIBAL / diethyl ether; toluene / 1 h / temperature below -70 deg C

2: 1. ZnBr₂, 2. trifluoroacetic acid (TFA) / 1. THF, r.t., overnight; 2. CH₂Cl₂, 5 min

3: 100 percent / CeCl₃*7H₂O, NaBH₄ / ethanol; methanol / 1 h / -78 °C

4: Et₃N, DMAP / CH₂Cl₂ / 0.08 h

5: 90 percent / aq. H₂SO₄, HgSO₄ / dioxane / 48 h

With dmap; sodium tetrahydroborate; cerium(III) chloride; sulfuric acid; diisobutylaluminium hydride; mercury(II) sulfate; triethylamine; trifluoroacetic acid; zinc dibromide; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1021/jo00026a031