(2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine

Base Information

• Chemical Name: (2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine
• CAS No.: 1262236-62-3
• Molecular Formula: C₁₈H₂₀ClNO₂S₂
• Molecular Weight: 381.947
• Mol file: 1262236-62-3.mol

Synonyms:(2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine

Chemical Property of (2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine

Chemical Property:

Purity/Quality:

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Technology Process of (2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine

There total 1 articles about (2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(S)(-)-N,O-bis(p-toluenesulphonyl)-2-hydroxymethyl pyrrolidine (52682-03-8) + p-Chlorothiophenol (106-54-7) → (2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine (1262236-62-3)

Guidance literature:

With sodium hydroxide; In ethanol; N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1039/c0ob00560f

Reference yield: 63.0%

(2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine (1262236-62-3) → (2S)-2-fluoromethyl-N-tosylpyrrolidine (1262236-65-6) + (2S)-2-dibromofluoromethyl-N-tosylpyrrolidine (1262236-63-4)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridinium polyhydrogenfluoride; In dichloromethane; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1039/c0ob00560f

Reference yield:

(2S)-2-(4-chlorophenylthiomethyl)-N-tosylpyrrolidine (1262236-62-3) → (3R)-3-fluoro-N-tosylpiperidine (1262236-64-5) + (2S)-2-difluoromethyl-N-tosylpyrrolidine (1262236-60-1) + (2S)-2-trifluoromethyl-N-tosylpyrrolidine (1262236-61-2) + (2S)-2-dibromofluoromethyl-N-tosylpyrrolidine (1262236-63-4)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridinium polyhydrogenfluoride; In dichloromethane; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1039/c0ob00560f

upstream raw materials:

(S)(-)-N,O-bis(p-toluenesulphonyl)-2-hydroxymethyl pyrrolidine

p-Chlorothiophenol

Downstream raw materials:

(3R)-3-fluoro-N-tosylpiperidine

(2S)-2-difluoromethyl-N-tosylpyrrolidine

(2S)-2-trifluoromethyl-N-tosylpyrrolidine

(2S)-2-dibromofluoromethyl-N-tosylpyrrolidine

Refernces