(E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide

Base Information

• Chemical Name: (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide
• CAS No.: 1384432-37-4
• Molecular Formula: C₁₃H₁₅NO₄S
• Molecular Weight: 281.332
• Mol file: 1384432-37-4.mol

Synonyms:(E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide

Chemical Property of (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide

There total 10 articles about (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide (1384432-41-0) → N-methyl-N-(4-methyl-5-phenylfuran-2-yl)methanesulfonamide + (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide (1384432-37-4)

Guidance literature:

With 8-methylquinoline 1-oxide; C₂₂H₂₇AuF₆NO₄PS₂*⁽³⁾H⁽¹⁺⁾; In 1,2-dichloro-ethane; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c2cc33030j

Reference yield: 45.0%

(E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide (1384432-41-0) → (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide (1384432-38-5) + N-methyl-N-(4-methyl-5-phenylfuran-2-yl)methanesulfonamide + (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide (1384432-37-4)

Guidance literature:

With silver hexafluoroantimonate; 8-methylquinoline 1-oxide; 2-(di-tert-butylphosphino)-1,1'-biphenylgold(I) chloride; In 1,2-dichloro-ethane; at 28 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c2cc33030j

Reference yield:

(E)-(4,4-dibromo-2-methylbuta-1,3-dien-1-yl)benzene (77295-77-3) → N-methyl-N-(4-methyl-5-phenylfuran-2-yl)methanesulfonamide + (E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide (1384432-37-4)

Guidance literature:

Multi-step reaction with 4 steps

1: n-butyllithium / hexane / 2.5 h / -78 - 20 °C

2: N-Bromosuccinimide; silver nitrate / acetone / 3 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium carbonate / toluene / 80 °C / Inert atmosphere

4: 8-methylquinoline 1-oxide; C₂₂H₂₇AuF₆NO₄PS₂*⁽³⁾H⁽¹⁺⁾ / 1,2-dichloro-ethane / 12 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; 1,10-Phenanthroline; 8-methylquinoline 1-oxide; copper(ll) sulfate pentahydrate; C₂₂H₂₇AuF₆NO₄PS₂*⁽³⁾H⁽¹⁺⁾; potassium carbonate; silver nitrate; In hexane; 1,2-dichloro-ethane; acetone; toluene;

DOI:10.1039/c2cc33030j

upstream raw materials:

(E)-(4-bromo-2-methylbut-1-en-3-yn-1-yl)benzene

(E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide

(E)-(4,4-dibromo-2-methylbut-1,3-dien-1-yl)benzene

(E)-(4,4-dibromo-2-methylbuta-1,3-dien-1-yl)benzene