(E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide

Base Information

• Chemical Name: (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide
• CAS No.: 1384432-41-0
• Molecular Formula: C₁₃H₁₅NO₂S
• Molecular Weight: 249.334
• Mol file: 1384432-41-0.mol

Synonyms:(E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide

Chemical Property of (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide

There total 4 articles about (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-methylmethane sulphonamide (1184-85-6) + (E)-(4-bromo-2-methylbut-1-en-3-yn-1-yl)benzene (1384432-67-0) → (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide (1384432-41-0)

Guidance literature:

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In toluene; at 80 ℃; Inert atmosphere;

DOI:10.1039/c2cc33030j

Reference yield:

α-methyl-trans-cinnamaldehyde (15174-47-7) → (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide (1384432-41-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine / dichloromethane / Inert atmosphere

2: n-butyllithium / hexane / 2.5 h / -78 - 20 °C

3: N-Bromosuccinimide; silver nitrate / acetone / 3 h / 20 °C / Inert atmosphere

4: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium carbonate / toluene / 80 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; silver nitrate; triphenylphosphine; In hexane; dichloromethane; acetone; toluene;

DOI:10.1039/c2cc33030j

Reference yield:

(E)-(4,4-dibromo-2-methylbut-1,3-dien-1-yl)benzene (80907-80-8) → (E)-N-methyl-N-(3-methyl-4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide (1384432-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 3 h / 20 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium carbonate / toluene / 80 °C / Inert atmosphere

With N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; silver nitrate; In acetone; toluene;

DOI:10.1039/c2cc33030j

upstream raw materials:

N-methylmethane sulphonamide

(E)-(4-bromo-2-methylbut-1-en-3-yn-1-yl)benzene

(E)-(4,4-dibromo-2-methylbut-1,3-dien-1-yl)benzene

(E)-(4,4-dibromo-2-methylbuta-1,3-dien-1-yl)benzene

Downstream raw materials:

(E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide

(E)-N,3-dimethyl-N-(methylsulfonyl)-2-oxo-4-phenylbut-3-enamide

N-(3-iodo-4-methyl-5-phenylfuran-2-yl)-N-methylmethanesulfonamide

benzaldehyde