(R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol

Base Information

• Chemical Name: (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol
• CAS No.: 126421-70-3
• Molecular Formula: C₂₇H₂₅F₃O₃
• Molecular Weight: 454.489
• Mol file: 126421-70-3.mol

Synonyms:(R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol

Chemical Property of (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol

There total 3 articles about (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) → (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol (126421-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydrogen carbonate, 2.) oxalyl chloride / 1.) water, 2.) benzene

2: 4-pyrrolidinopyridine / CCl₄

With oxalyl dichloride; sodium hydrogencarbonate; 4-pyrrolidin-1-ylpyridine; In tetrachloromethane;

DOI:10.1021/ja00165a036

Reference yield:

2,2-diphenylcyclopentanone (15324-42-2) → (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol (126421-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 120 h / Ambient temperature

2: 4-pyrrolidinopyridine / CCl₄

With (+)-β-chlorodiisopinocampheylborane; 4-pyrrolidin-1-ylpyridine; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/ja00165a036

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (R)-(-)-2,2-diphenylcyclopentanol (126421-67-8) → (R)-MTPA ester of (R)-(-)-2,2-diphenylcyclopentanol (126421-70-3)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; In tetrachloromethane; Yield given;

DOI:10.1021/ja00165a036

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-(-)-2,2-diphenylcyclopentanol

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

2,2-diphenylcyclopentanone

Refernces