2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

Base Information

Chemical Name:2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide
CAS No.:1350712-62-7
Molecular Formula:C₂₃H₃₆N₄O₂Si
Molecular Weight:428.65
Hs Code.:

Synonyms:2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

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Chemical Property of 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

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Technology Process of 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

There total 7 articles about 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1185428-39-0
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

: 3218-02-8
cyclohexylmethylamine

: 1350712-62-7
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

Guidance literature:: 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 0.75h;

cyclohexylmethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 1334674-88-2
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350712-62-7
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Jones reagent / acetone / 0.25 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

4.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 2 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.75 h / 60 °C

5.2: 3 h / 20 °C

With sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; sodium hydride; 1,1'-carbonyldiimidazole; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;

Reference yield:

: 1334674-87-1
(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350712-62-7
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / tetrahydrofuran

1.2: pH 4

2.1: Jones reagent / acetone / 0.25 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 1 h / 0 - 20 °C

4.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

5.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 2 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.75 h / 60 °C

6.2: 3 h / 20 °C

With sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; 1,1'-carbonyldiimidazole; sodium hydroxide; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;