methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide

Base Information

• Chemical Name: methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide
• CAS No.: 1375082-71-5
• Molecular Formula: C₁₃H₁₉ClO₈P₂
• Molecular Weight: 400.69
• Mol file: 1375082-71-5.mol

Synonyms:methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide

Chemical Property of methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide

There total 2 articles about methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-Methyl mandelate (21210-43-5) + methyl [chloro(dimethoxyphosphoryl)methyl]phosphonate → methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide (1375082-71-5)

Guidance literature:

DOI:10.1021/acs.joc.0c01204

Reference yield: 65.0%

sodium methyl[chloro(dimethoxyphosphoryl)methyl]phosphonate (1375082-69-1) + (R)-methyl mandelate (20698-91-3) → methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide (1375082-71-5)

Guidance literature:

sodium methyl[chloro(dimethoxyphosphoryl)methyl]phosphonate; In methanol;

(R)-methyl mandelate; With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja300218x

Reference yield:

methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide (1375082-71-5) → methyl (2S)-({[chloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(phenyl)ethanoate

Guidance literature:

methyl (7S)-7-phenyl-4-chloro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide; With trimethylsilyl bromide; In acetonitrile; at 20 ℃; for 1h;

With methanol; at 20 ℃; for 0.25h;

DOI:10.1021/ja300218x

upstream raw materials:

sodium methyl[chloro(dimethoxyphosphoryl)methyl]phosphonate

(R)-methyl mandelate

(S)-Methyl mandelate