(4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

Base Information

Chemical Name:(4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine
CAS No.:929006-86-0
Molecular Formula:C₃₀H₄₅NO₄Si
Molecular Weight:511.777
Hs Code.:

Synonyms:(4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

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Chemical Property of (4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

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Technology Process of (4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

There total 6 articles about (4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3-(((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)oxiran-2-yl)methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 929006-86-0
(4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

: 929006-85-9
(4R,5S)-N,N-dibenzyl-4-(((2R,3R)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1021/ol062804a

Reference yield:

: 929006-83-7
(2S,3R)-2-(dibenzylamino)hept-5-yne-1,3,7-triol

: 929006-86-0
(4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: CSA / acetone / 2 h / 50 °C

1.2: 79 percent / acetic acid / tetrahydrofuran; H₂O / 1 h / 20 °C

2.1: 78 percent / Red-Al / diethyl ether; toluene / 20 h / -10 - 20 °C

3.1: mCPBA / CH₂Cl₂ / 0.07 h / 20 °C

4.1: 41.2 mg / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; camphor-10-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol062804a

Reference yield:

: 929006-71-3
(E)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)but-2-en-1-ol

: 929006-86-0
(4R,5S)-N,N-dibenzyl-4-(((2S,3S)-3-((tert-butyldimethylsilyloxy)methyl)oxiran-2-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: mCPBA / CH₂Cl₂ / 0.07 h / 20 °C

2: 41.2 mg / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol062804a