2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine

Base Information

• Chemical Name: 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine
• CAS No.: 252259-67-9
• Molecular Formula: C₃₈H₃₈N₄O₃
• Molecular Weight: 598.745
• Mol file: 252259-67-9.mol

Synonyms:2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine

Chemical Property of 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine

There total 4 articles about 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2,3,4,5-Tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-1H-1,4-benzodiazepine (195983-63-2) + 1-triphenylmethyl-4-imidazolyl-acetic acid (168632-03-9) → 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine (252259-67-9)

Guidance literature:

1-triphenylmethyl-4-imidazolyl-acetic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -30 ℃; for 0.166667h;

2,3,4,5-Tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-1H-1,4-benzodiazepine; In tetrahydrofuran; for 7h;

DOI:10.1021/jm990391w

Reference yield:

1,4-benzodiazepine-2,5-dione (5118-94-5) → 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine (252259-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LAH / tetrahydrofuran / 18 h / Heating

2.1: 350 mg / tetrahydrofuran / 18 h

3.1: isobutyl chloroformate; Et₃N / tetrahydrofuran / 0.17 h / -30 °C

3.2: 48 percent / tetrahydrofuran / 7 h

With lithium aluminium tetrahydride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1.1: Reduction / 2.1: Acylation / 3.1: Acylation / 3.2: Acylation;

DOI:10.1021/jm990391w

Reference yield:

2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine (5946-39-4) → 2,3,4,5-tetrahydro-1-[1-oxo-2-(1-triphenylmethylimidazol-4-yl)ethyl]-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine (252259-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 350 mg / tetrahydrofuran / 18 h

2.1: isobutyl chloroformate; Et₃N / tetrahydrofuran / 0.17 h / -30 °C

2.2: 48 percent / tetrahydrofuran / 7 h

With triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1.1: Acylation / 2.1: Acylation / 2.2: Acylation;

DOI:10.1021/jm990391w

upstream raw materials:

2,3,4,5-Tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-1H-1,4-benzodiazepine

1-triphenylmethyl-4-imidazolyl-acetic acid

1,4-benzodiazepine-2,5-dione

2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine