tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Base Information

Chemical Name:tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate
CAS No.:1374263-25-8
Molecular Formula:C₄₀H₄₀N₆O₃
Molecular Weight:652.796
Hs Code.:

Synonyms:tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

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Chemical Property of tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

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Technology Process of tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

There total 9 articles about tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 123-75-1
pyrrolidine

: 1374263-15-6
4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]benzoic acid

: 1374263-25-8
tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374263-25-8
tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: Lawessons reagent; pyridine / 18 h / 100 °C

2: 1 h / 95 °C

3: acetic acid / 13 h / 105 °C

4: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6: N-chloro-succinimide / chloroform / 22 h / Reflux

7: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

8: hydrogen / palladium 10% on activated carbon / methanol / 24.5 h / 50 °C

9: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With Lawessons reagent; pyridine; N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1204296-84-3
5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione

: 1374263-25-8
tert-butyl [1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: 1 h / 95 °C

2: acetic acid / 13 h / 105 °C

3: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

5: N-chloro-succinimide / chloroform / 22 h / Reflux

6: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

7: hydrogen / palladium 10% on activated carbon / methanol / 24.5 h / 50 °C

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;