1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

Base Information

Chemical Name:1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester
CAS No.:1380650-70-3
Molecular Formula:C₃₂H₃₂N₂O₅
Molecular Weight:524.616
Hs Code.:

Synonyms:1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

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Chemical Property of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

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Technology Process of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

There total 6 articles about 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1380650-69-0
5-(4'-(1-(isopropoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylic acid

: 1380650-70-3
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 1h;

Reference yield:

: 31603-77-7
4-biphenylacetonitrile

: 1380650-70-3
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 48 h / 20 - 80 °C

2.1: potassium hydroxide; water / ethylene glycol / 3 h / 170 °C

3.1: thionyl chloride / 4 h / 65 °C

3.2: 65 °C

4.1: aluminum (III) chloride / dichloromethane / 1.5 h / 20 °C

5.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 20 °C

6.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 75 °C

6.2: 20 °C

7.1: hydroxylamine hydrochloride / acetic acid / 0.5 h / 100 °C

8.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 20 °C

8.2: pH 2

9.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

With aluminum (III) chloride; thionyl chloride; diphenyl phosphoryl azide; hydroxylamine hydrochloride; tetrabutylammomium bromide; water; bromine; triethylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethylene glycol; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1380650-64-5
1-(biphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester

: 1380650-70-3
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 75 °C

3.2: 20 °C

4.1: hydroxylamine hydrochloride / acetic acid / 0.5 h / 100 °C

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 20 °C

5.2: pH 2

6.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

With aluminum (III) chloride; thionyl chloride; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; bromine; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;