1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Base Information

Chemical Name:1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt
CAS No.:1380650-53-2
Molecular Formula:C₂₉H₂₅N₂O₅*Na
Molecular Weight:504.518
Hs Code.:

Synonyms:1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Suppliers and Price of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

There total 19 articles about 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257213-50-5
(R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

: 1380650-53-2
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Guidance literature:: With sodium hydroxide; In ethanol; n-heptane;

Reference yield:

: 92855-14-6
1-(biphenyl-4-yl)cyclopropanecarbonitrile

: 1380650-53-2
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium hydroxide; water / ethylene glycol / 3 h / 170 °C

2.1: thionyl chloride / 4 h / 65 °C

2.2: 65 °C

3.1: aluminum (III) chloride / dichloromethane / 1.5 h / 20 °C

4.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 20 °C

5.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 75 °C

5.2: 20 °C

6.1: hydroxylamine hydrochloride / acetic acid / 0.5 h / 100 °C

7.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 20 °C

7.2: pH 2

8.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 5 h / 65 °C

10.1: sodium hydroxide / n-heptane; ethanol

With aluminum (III) chloride; thionyl chloride; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; bromine; triethylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; ethylene glycol; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 93022-07-2
1-(biphenyl-4-yl)cyclopropanecarboxylic acid

: 1380650-53-2
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

4.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

4.2: 2 h / 50 °C

5.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere

7.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

8.1: lithium hydroxide / methanol / 2 h / 65 °C

9.1: sodium hydroxide / n-heptane; ethanol

With aluminum (III) chloride; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; hydrogen; bromine; triethylamine; sodium hydroxide; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;